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Adverse effects of COVID-19 vaccine in the paediatric population: a focus on the cardiovascular system
Ghena Lababidi1, Hossam Lababidi2, Fadi Bitar1
1Department of Pediatrics, Children's Heart Centre, American University of Beirut, Beirut, Lebanon.
Insights
This review examines severe adverse events following COVID-19 vaccination in children. It finds no significant risks, emphasizing vaccine safety for pediatric populations.
Area of Science:
- Immunology
- Public Health
- Pediatrics
Background:
- The COVID-19 pandemic necessitated rapid vaccine development and deployment.
- Vaccines were initially approved for adults, with pediatric use following.
- Post-licensure surveillance identified adverse events in both adult and pediatric cohorts.
Purpose of the Study:
- To assess the risk profile of severe adverse events in pediatric COVID-19 vaccination.
- To review the classification and presentation of serious adverse events in children.
- To emphasize cardiovascular severe adverse events and adverse events in the pediatric population.
Main Methods:
- Literature review of reported severe adverse events.
- Analysis of classification and presentation of adverse events.
- Focus on cardiovascular adverse events in pediatric cohorts.
Main Results:
- Review of existing literature on pediatric COVID-19 vaccine adverse events.
- Analysis indicates a low incidence of severe adverse events in children.
- Cardiovascular events are specifically examined within the context of overall safety.
Conclusions:
- Current evidence suggests that COVID-19 vaccination is safe for pediatric populations.
- The study underscores the importance of ongoing monitoring for vaccine safety.
- Future perspectives on vaccine immunology and pandemic control are discussed.
Abstract:
The COVID-19 pandemic had an unprecedented impact on healthcare systems and exists globally. To control pandemic progression, COVID-19 vaccines were developed and licensed for use in the adult population in early 2021 and became available in paediatric cohorts several months later. Since then, several studies have reported adverse events and severe adverse events in the adult and paediatric cohorts. The question remains whether there exists a significant risk to paediatric COVID-19 vaccination. This study reviews the classification and presentation of severe adverse events and discusses relevant reports in the literature. An emphasis is put on cardiovascular severe adverse events and adverse events. This paper also provides current and future perspectives relative to the pandemic, its control, and the future of vaccine immunology.
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