Low Expression of Mitochondrial Ribosomal Protein S5 is Associated With Poor Prognosis in Patients With Clear Cell Renal Cell Carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Mitochondrial ribosomal protein S5 (MRPS5) is underexpressed in clear cell renal cell carcinoma (ccRCC). Low MRPS5 expression is linked to poorer patient survival and serves as a potential prognostic biomarker for ccRCC.
Area Of Science
- Oncology
- Molecular Biology
- Biomarker Discovery
Background
- Mitochondrial ribosomal protein S5 (MRPS5) exhibits altered expression in various cancers.
- Its role in clear cell renal cell carcinoma (ccRCC) and its prognostic significance remain underexplored.
Purpose Of The Study
- To investigate the relationship between MRPS5 expression and patient prognosis in ccRCC.
- To evaluate MRPS5 as a potential prognostic biomarker for ccRCC.
Main Methods
- Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting were used to assess MRPS5 in fresh tumoral and peritumoral tissues.
- Immunohistochemical staining and scoring evaluated MRPS5 expression in paraffin-embedded ccRCC tissues.
- Statistical analyses, including Kaplan-Meier and multivariate analysis, correlated MRPS5 expression with clinicopathological parameters and patient survival.
Main Results
- MRPS5 mRNA and protein levels were significantly lower in ccRCC tumoral tissues compared to peritumoral tissues.
- High MRPS5 expression was observed in 61.9% of 160 ccRCC samples.
- MRPS5 expression correlated significantly with T classification, TNM stage, and Fuhrman grade.
- Low MRPS5 expression was associated with poorer overall survival and recurrence-free survival.
- Multivariate analysis confirmed MRPS5 as an independent predictor of survival.
Conclusions
- MRPS5 expression is significantly reduced in ccRCC tissues.
- Low MRPS5 expression is a risk factor and an independent predictor of poor prognosis in ccRCC patients.
- MRPS5 holds potential as a novel prognostic biomarker for ccRCC.
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