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Reduced OTUD7B expression correlates with poor prognosis in PTCL via non-canonical NF-κB
Feng Chen1, Shi Qiu1, Ailing Gui1
1Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
International Journal of Hematology
|December 5, 2024
Summary
Low ovarian tumor domain-containing 7B (OTUD7B) expression predicts poor outcomes in Peripheral T cell lymphoma (PTCL). OTUD7B may be a therapeutic target, with drug combinations showing promise for PTCL treatment.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Peripheral T cell lymphoma (PTCL) is aggressive with poor prognosis.
- Effective biomarkers are needed for PTCL therapeutic strategies.
- Ovarian tumor domain-containing 7B (OTUD7B) is implicated in cancer progression.
Purpose of the Study:
- To investigate the prognostic significance of OTUD7B in PTCL.
- To explore the role of OTUD7B in PTCL chemoresistance.
- To evaluate potential therapeutic strategies targeting OTUD7B in PTCL.
Main Methods:
- Analysis of OTUD7B expression in PTCL patients.
- OTUD7B knockdown in PTCL cell lines.
- Assessment of chemoresistance to doxorubicin.
- Investigation of non-canonical NF-κB pathway.
- Evaluation of 5-azacytidine and cytarabine in combination therapy.
Main Results:
- Low OTUD7B expression correlated with shorter progression-free survival (PFS) and overall survival (OS).
- OTUD7B knockdown increased doxorubicin chemoresistance via p52 nuclear translocation.
- Inhibition of non-canonical NF-κB partially restored doxorubicin sensitivity.
- 5-azacytidine and cytarabine upregulated OTUD7B and showed synergistic anti-lymphoma effects.
Conclusions:
- OTUD7B serves as a prognostic biomarker in PTCL.
- Targeting OTUD7B and combining epigenetic drugs with chemotherapy offers a promising therapeutic approach for PTCL.
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