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Related Experiment Video

Updated: Jun 5, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Retinal Vascular Changes in Vitiligo: A Novel Approach Using OCTA.

Kübra Özata Gündoğdu¹, Emine Doğan¹, Reyhan Çetinkaya²

¹Sakarya University Education and Research Hospital, Department of Ophthalmology, Sakarya, Turkey.

Ocular Immunology and Inflammation

|December 5, 2024

Summary

Vitiligo patients showed reduced temporal retinal nerve fiber layer thickness. Ocular tissue changes in vitiligo require further investigation with larger studies.

Keywords:

Foveal avascular zone area VASI optic coherence tomography optic coherence tomography angiography vitiligo

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Last Updated: Jun 5, 2025

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Published on: May 26, 2023

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Published on: January 12, 2022

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Published on: April 21, 2022

Area of Science:

Ophthalmology
Dermatology
Medical Imaging

Background:

Vitiligo is an autoimmune condition causing melanocyte loss.
Ocular tissues may be affected by vitiligo due to melanocyte presence.

Purpose of the Study:

To detect structural and functional retinal and choroidal changes in vitiligo patients.
Utilize optical coherence tomography (OCT) and OCT angiography (OCTA) for assessment.

Main Methods:

Compared 30 vitiligo patients with 30 healthy controls.
Measured central macular thickness (CMT), retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT), foveal avascular zone (FAZ) area, and vascular density (VD) using OCT and OCTA.

Main Results:

Temporal RNFL thickness was significantly lower in vitiligo patients.
No significant differences in CMT, other RNFL quadrants, CT, FAZ area, or superficial/deep VD between groups.
Negative correlation found between vitiligo duration and RNFL/VD values.

Conclusions:

Vitiligo may impact RNFL thickness, particularly in the temporal quadrant.
No significant effect on retinal vascular density observed, contrary to expectations.
Further research with larger, diverse populations is warranted to fully understand ocular implications of vitiligo.