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Retinal Vascular Changes in Vitiligo: A Novel Approach Using OCTA
Kübra Özata Gündoğdu1, Emine Doğan1, Reyhan Çetinkaya2
1Sakarya University Education and Research Hospital, Department of Ophthalmology, Sakarya, Turkey.
Purpose:
This study aimed to the detect of structural and functional changes in the retina and choroid in patients with vitiligo using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).
Materials And Methods:
Thirty patients with vitiligo and 30 healthy participants were enrolled in the study. Central macular thickness (CMT), retina nerve fiber layer (RNFL) thickness, choroidal thickness (CT), foveal avascular zone (FAZ) area, and superficial and deep vascular density (VD) ratios were compared between the groups.
Results:
The mean age was 43.32 ± 12.13 and 45.90 ± 7.50 years, respectively (p = 0.435). CMT, RNFL thicknesses (except temporal quadrant), CT, superficial and deep VD, and FAZ area were similar between the two groups (p > 0.05 for all). Temporal RNFL thicknesses were lower in vitiligo patients than in control groups (p = 0.005). There was a moderate negative correlation between the duration of vitiligo disease and the mean RNFL thickness, inferior RNFL thickness, superficial total, superior, superior inner, outer, and superior outer VD values. No correlation was found between the VASI (Vitiligo area scoring index) score in vitiligo patients and OCT and OCTA values.
Conclusion:
Although it is known that vitiligo causes melanocyte loss in ocular tissues, there was no significant effect of vitiligo on superficial and deep retinal VD. Further comprehensive studies with a larger and more diverse population of vitiligo patients are needed to explore this further.
