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[The Role of the Left Atrium in the Pathogenesis of Heart Failure With Preserved Ejection Fraction]

A G Ovchinnikov1, A V Potekhina2, A Yu Filatova2

  • 1Chazov National Medical Research Center of Cardiology, Moscow; Russian University of Medicine, Moscow.

Kardiologiia
|December 5, 2024
PubMed

Insights

Left atrial myopathy contributes to heart failure with preserved ejection fraction (HFpEF) and predicts a poor prognosis. Echocardiography, particularly left atrial strain, aids in diagnosing HFpEF and guiding treatment for this condition.

Area of Science:

  • Cardiology
  • Cardiac Physiology

Background:

  • Left atrial dysfunction, or myopathy, is integral to heart failure with preserved ejection fraction (HFpEF) pathophysiology.
  • It is linked to more severe HFpEF and worse patient outcomes.
  • Treatment decisions for HFpEF are often guided by the severity of left atrial myopathy.

Purpose of the Study:

  • To explore the role of the left atrium in left ventricular filling.
  • To examine left atrial status across different stages of left ventricular diastolic dysfunction.
  • To discuss mechanisms and therapeutic strategies for left atrial myopathy in HFpEF.

Main Methods:

  • Echocardiography for assessing left atrial condition.
  • Analysis of left atrial myocardial strain parameters.
  • Review of current literature on left atrial myopathy in HFpEF.

Main Results:

  • Left atrial myocardial strain parameters are sensitive indicators of early functional impairment.
  • These parameters assist in diagnosing HFpEF.
  • Left atrial myopathy severity influences prognosis and treatment selection.

Conclusions:

  • Left atrial myopathy is a key factor in HFpEF.
  • Echocardiographic assessment of left atrial function is crucial for HFpEF management.
  • Understanding atrial myopathy mechanisms can lead to targeted therapies.

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