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Updated: Jun 5, 2025

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
Cancer research in South Asian Association for Regional Cooperation (SAARC) countries
M Saiful Huq1, Sandhya C Acharya2, Manish Gautam3
1Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Cancer research investment lags in South Asian Association for Regional Cooperation (SAARC) countries despite rising incidence. Strengthening local research capacity is crucial for developing applicable and affordable cancer therapies.
Area of Science:
- Oncology
- Global Health
- Health Policy
Background:
- Cancer poses a significant global health challenge, with projected increases in low- and middle-income countries.
- A substantial disparity exists in cancer research investment and output between high-income nations and South Asian Association for Regional Cooperation (SAARC) countries.
- Rising cancer incidence in SAARC nations is not paralleled by local research, particularly in advanced areas like clinical trials for molecular biology, targeted therapy, immunotherapy, and cancer vaccines.
Purpose of the Study:
- To examine the current state of cancer research within SAARC countries, including Bangladesh, Nepal, Sri Lanka, India, Pakistan, Afghanistan, Bhutan, and Maldives.
- To analyze publication rates, research infrastructure, ongoing studies, and limitations in cancer research across SAARC nations.
- To identify key challenges and propose strategies for strengthening cancer research capacity in the region.
Main Methods:
- Analysis of PubMed publication rates for cancer research in SAARC countries.
- Assessment of existing research infrastructure and current clinical trial landscape.
- Review of limitations and disparities in cancer research among SAARC member states.
Main Results:
- Significant gaps in cancer research investment and output compared to high-income countries.
- Limited local research, especially in clinical trials for advanced cancer therapies.
- Key challenges identified include healthcare access disparities, socioeconomic barriers, and inadequate funding and infrastructure.
Conclusions:
- Cancer research in SAARC countries faces substantial hurdles, including funding, infrastructure, and applicability of Western-developed guidelines.
- Strengthening cancer research necessitates collaborative networks, improved facilities, local epidemiological studies, and development of affordable treatments.
- Policy interventions and stakeholder engagement are vital for advancing cancer care in the SAARC region.
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