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Updated: Jun 5, 2025

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
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Emerging targets in gastric and pancreatic cancer: Focus on claudin 18.2

Alireza Tojjari1, Yassine Alami Idrissi1, Anwaar Saeed2

  • 1Department of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15213, USA.

Cancer Letters
|December 5, 2024
PubMed

Insights

Claudin 18.2 (CLDN18.2) is a promising target for gastric and pancreatic cancers. Therapies targeting CLDN18.2 show potential but require careful patient selection and management of resistance and toxicity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Claudin 18.2 (CLDN18.2) is a tight junction protein selectively expressed in gastric and pancreatic cancer cells.
  • Its restricted expression in normal tissues makes CLDN18.2 an attractive target for novel cancer therapies.

Purpose of the Study:

  • To review the therapeutic landscape and clinical advancements in targeting Claudin 18.2.
  • To discuss the potential and challenges of CLDN18.2-targeted therapies in gastric and pancreatic cancers.

Main Methods:

  • Review of early-phase clinical trials and preclinical studies.
  • Analysis of therapeutic strategies including monoclonal antibodies, bispecific antibodies, and antibody-drug conjugates.

Main Results:

  • CLDN18.2-targeted therapies demonstrate significant antitumor activity, especially in combination regimens.
  • Monoclonal antibodies like zolbetuximab show promise in clinical trials.

Conclusions:

  • Targeting CLDN18.2 represents a significant advancement in treating gastric and pancreatic cancers.
  • Further research is needed to address patient selection, resistance, and toxicity for optimal therapeutic outcomes.
Keywords:
Antibody-drug conjugatesBispecific antibodiesCART cellClaudin 18.2Gastric cancerMonoclonal antibodiesPancreatic cancer

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