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Invasive Inguinal Lymph Node Recurrence of a Perineal Rhabdomyosarcoma
Megan A Stout1, Leslie Peard2, Daniel J Benedetti3
1Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN.
Abstract:
Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma derived from embryonic mesenchymal tissue. RMS can be found anywhere in the body, including the head and neck, extremities, pelvis, and genitourinary tract. Perineal-RMS is a rare and aggressive form of RMS. Patients often have a delayed presentation following onset of symptoms and frequently present with regional lymph node involvement and/or distant metastases. Primary tumor site is an important prognostic factor for RMS, with the perineal region being considered an unfavorable location. We present a case of Perineal RMS in a 6-year-old boy who later developed an invasive inguinal lymph node recurrence.
Insights
This case study highlights aggressive Perineal Rhabdomyosarcoma (RMS) in a child. It emphasizes delayed diagnosis and the risk of invasive inguinal lymph node recurrence, an unfavorable prognostic factor.
Area of Science:
- Pediatric Oncology
- Sarcoma Research
- Soft Tissue Tumors
Background:
- Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma originating from embryonic mesenchymal tissue.
- Perineal RMS is a rare and aggressive subtype, often presenting late with lymph node or distant metastasis.
- The perineal location is a significant unfavorable prognostic factor in RMS.
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