Synthesis and characterization of interpenetrating network hydrogels based on sugar beet pectin and heteroprotein...

Hydrogels made from natural polymers have excellent application potential due to their good biocompatibility. However, it is difficult to maximise the benefits of hydrogels when the gel network is formed by a single substance. The purpose of this study was to investigate the relationship between the interaction of modified soybean lipophilic proteins (SLP) and lysozyme (LY) and the formation of heteroprotein complexes. Subsequently, interpenetrating network (IPN) hydrogels were further synthesized on the basis of heteroprotein (HP) complexes and sugar beet pectin (SBP) as the backbone. The strong interaction between SLP and LY drove them to spontaneously form heteroprotein complexes. The HP-SBP IPN imparted good mechanical properties to the hydrogel, which could withstand a maximum pressure of 7500 pa at 88 % strain. Meanwhile, there was still 93.52 % of water being trapped in IPN after freeze-thawing. The HP-SBP IPN hydrogels could effectively protect the encapsulated substance during UV irradiation and maintain its morphology after undergoing dynamic pH changes. Furthermore, the HP-SBP IPN hydrogels could regulate their release ability through their own swelling and achieved more than 88 % release rate in simulated intestinal fluid. Therefore, this study was expected to provide a potential strategy for the synthesis of IPN hydrogels.