Polysaccharide-based hydrogels for atopic dermatitis management: A review

Area of Science:

• Dermatology and Materials Science
• Focus on advanced wound care and drug delivery systems.

Background:

• Atopic dermatitis (AD) is a prevalent, burdensome skin disease affecting millions globally.
• Genetic factors impact skin barrier integrity and immune responses in AD.
• Current treatments like emollients face compliance issues, while medicated options carry risks.

Purpose of the Study:

• To review the potential of hydrogels as an alternative treatment for atopic dermatitis (AD).
• To explore polysaccharide-based hydrogels for improved AD management.
• To highlight advantages over conventional treatments, including enhanced compliance and reduced side effects.

Main Methods:

• Review of scientific literature on hydrogels for AD management.
• Focus on polysaccharide-based hydrogels (alginate, cellulose, chitosan, hyaluronic acid).
• Exploration of hydrogel fabrication, application methods, and AD models.

Main Results:

• Hydrogels offer superior skin hydration due to high water retention.
• Polysaccharide hydrogels show potential for enhanced drug delivery and reduced systemic side effects.
• Hydrogels improve patient compliance through non-greasy texture and reduced application frequency.

Conclusions:

• Hydrogels represent a promising therapeutic strategy for atopic dermatitis (AD).
• Polysaccharide-based hydrogels are particularly suitable for AD management.
• Further research into hydrogel application methods and AD models is warranted.