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Updated: Jun 5, 2025

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
Published on: July 12, 2024
Association between automatic AI-based quantification of airway-occlusive mucus plugs and all-cause mortality in
Tjeerd van der Veer1,2, Eleni-Rosalina Andrinopoulou3,4, Gert-Jan Braunstahl5,6
1Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands t.vanderveer@lumc.nl.
Abstract:
In this cohort study involving 9399 current and former smokers from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease study, we assessed the relationship between artificial intelligence-quantified mucus plugs on chest CTs and all-cause mortality. Our results revealed a significant positive association, particularly for those with COPD GOLD stages 1-4, with HRs of 1.18 for 1-2 mucus-obstructed bronchial segments and 1.27 for ≥3 obstructed segments. This corroborates previous visual mucus plug counting research and demonstrates the relevance of mucus plugs in COPD pathology and as a marker for risk assessment. Automated mucus plug quantification methods may provide an efficient tool for both clinical evaluations and research.
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