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Adolescent Superficial CD34-Positive Fibroblastic Tumor With Unique IHC Profile.

Scott Kuan-Wen Wang¹, Srinivas Mandavilli¹

¹Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut, USA.

Journal of Cutaneous Pathology

|December 5, 2024

Summary

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm. This case highlights a young patient with SCD34FT featuring PRDM10 rearrangement and unique cytokeratin expression, showing tumor diversity.

Keywords:

CD34‐positive PRDM10 cytokeratin fibroblastic tumor

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Area of Science:

Oncology
Pathology
Genetics

Background:

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently identified soft tissue neoplasm.
SCD34FT is classified in the WHO Soft Tissue and Bone Tumors Classification (5th ed.).
PRDM10 rearrangement in a subset of SCD34FTs suggests shared pathogenic pathways with other PRDM10-rearranged tumors.

Observation:

A case of a 16-year-old patient with SCD34FT on the forearm is presented.
The tumor exhibited PRDM10 rearrangement.
Unique, diffuse cytokeratin (CK AE1/AE3) expression was observed.

Findings:

The case represents one of the youngest diagnoses of SCD34FT.
The co-occurrence of PRDM10 rearrangement and diffuse CK AE1/AE3 expression in SCD34FT is notable.
This finding expands the known pathological spectrum of SCD34FT.

Implications:

This case contributes to understanding the clinical and pathological diversity of SCD34FT.
It underscores the importance of molecular markers like PRDM10 rearrangement in soft tissue tumor classification.
Further research into shared pathogenic mechanisms in PRDM10-rearranged tumors is warranted.