Related Experiment Video
Updated: Jun 5, 2025
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Cardiovascular health and transgender medicine]
Marc Blondon1, Alessandro Casini1, Marc Righini1
1Service d'angiologie et d'hémostase, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Gender dysphoria, which describes the distress related to the incongruence between a transgender person's experienced gender and their assigned sex at birth, can be alleviated by specific treatments, notably through gender-affirming hormone therapy and surgeries. Transgender people suffer from an excess of cardiovascular and thrombotic risk, of multifactorial origin and influenced by hormonal therapies and surgeries. In this article, we describe the basis of hormonal treatments for transgender people. The associated thrombotic and cardiovascular risks are detailed, along their mechanisms. Finally, the clinical situations and patient profiles requiring a specialized consultation when making decisions about gender-affirming treatment are discussed.
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