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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Selenium and Triple Negative Breast Cancer.

Despoina Sidira1, Angeliki Siafaka2, Dimosthenis Chrysikos3

  • 1Medical School, National and Kapodistrian University of Athens, Athens, Greece. despinasidirag@gmail.com.

Acta Medica Academica
|December 6, 2024
PubMed
Summary
This summary is machine-generated.

Selenium compounds show promise as an adjuvant therapy for triple-negative breast cancer (TNBC). This research indicates selenium enhances chemotherapy effectiveness and reduces cancer cell growth and metastasis.

Keywords:
AntioxidantsOncologySeleniumTriple Negative Breast Cancer

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Area of Science:

  • Oncology
  • Nutritional Biochemistry
  • Pharmacology

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies, contributing significantly to breast cancer mortality.
  • TNBC is defined by the absence of estrogen, progesterone, and HER2 receptors, necessitating novel treatment strategies.
  • Current treatment limitations underscore the need for therapeutic modalities with improved safety profiles.

Purpose of the Study:

  • To explore the therapeutic potential of selenium compounds as an adjunct treatment for TNBC.
  • To evaluate selenium's efficacy alone and in combination with nutritional supplements and chemotherapy.

Main Methods:

  • A systematic literature search was performed on PubMed using keywords "selenium" and "triple negative breast cancer".
  • Inclusion criteria involved studies on TNBC cell lines or in vivo models, published in English, with statistically significant results.
  • Thirteen relevant articles were selected and reviewed for their findings on selenium's effects.

Main Results:

  • Selenium therapy demonstrated synergistic effects with anti-cancer drugs, enhancing their efficacy.
  • Selenium compounds exhibited significant tumor cytotoxicity, reducing cancer cell proliferation and metastasis.
  • Observed effects included a reduction in hyperproliferation and invasive characteristics of TNBC cells.

Conclusions:

  • The review assessed various selenium compounds, experimental models, and affected cellular pathways in TNBC.
  • Preliminary findings suggest selenium compounds may offer benefits as co-therapeutic agents in TNBC treatment.
  • Further research is warranted to validate selenium compounds as effective adjunct therapies for TNBC.