Application of multi-feature-based machine learning models to predict neurological outcomes of cardiac arrest

Cardiac arrest (CA) is a major disease burden worldwide and has a poor prognosis. Early prediction of CA outcomes helps optimize the therapeutic regimen and improve patients' neurological function. As the current guidelines recommend, many factors can be used to evaluate the neurological outcomes of CA patients. Machine learning (ML) has strong analytical abilities and fast computing speed; thus, it plays an irreplaceable role in prediction model development. An increasing number of researchers are using ML algorithms to incorporate demographics, arrest characteristics, clinical variables, biomarkers, physical examination findings, electroencephalograms, imaging, and other factors with predictive value to construct multi-feature prediction models for neurological outcomes of CA survivors. In this review, we explore the current application of ML models using multiple features to predict the neurological outcomes of CA patients. Although the outcome prediction model is still in development, it has strong potential to become a powerful tool in clinical practice.