Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cost Analysis of an Outpatient MRI Pathway for Optic Disc Edema: A Time-Driven Activity-Based Costing Approach.

American journal of ophthalmology·2026

Same author

Evaluation for Potential Inequities in Efficacy and Patient Outcomes Following Implementation of a STAT Outpatient Neuroimaging Pathway for Evaluation of Patients with Optic Disc Swelling.

Neuro-ophthalmology (Aeolus Press)·2026

Same author

Clinical features of high intracranial pressure and prevalence of idiopathic intracranial hypertension among patients presenting with spontaneous CSF leaks.

Neurosurgical focus·2026

Same author

Evaluation of Racial, Ethnic, and Socioeconomic Disparities in Idiopathic Intracranial Hypertension.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2025

Same author

Alternating Bilateral Painful Ophthalmoplegia.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2025

Same author

Case report: ocular manifestations of <i>NFIX</i>-associated Malan syndrome.

Ophthalmic genetics·2025

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Case report: HLA-B35-associated optic neuritis.

Florian H Guillot¹, Andrew R Carey¹

¹Division of Neuro-Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Frontiers in Ophthalmology

|December 6, 2024

Summary

A rare case of optic neuritis linked to HLA-B35 was observed. This finding suggests exploring human leukocyte antigen (HLA) testing for unusual optic neuritis presentations.

Keywords:

Behçets disease HLA-B35 human leukocyte antigen optic neuritis optic neuropathy

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Published on: November 12, 2020

Related Experiment Videos

Last Updated: Jun 18, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Published on: November 12, 2020

Area of Science:

Ophthalmology
Immunogenetics

Background:

Optic neuritis is an inflammatory condition affecting the optic nerve.
Human Leukocyte Antigen (HLA) associations are known for various autoimmune and inflammatory diseases.

Observation:

A patient presented with unilateral retro-orbital pain, decreased vision, optic disc edema, and new-onset aphthous ulcers.
Diagnostic imaging revealed retrobulbar optic nerve enhancement.
Genetic testing identified the presence of HLA-B35.

Findings:

The patient's symptoms resolved rapidly with high-dose oral steroids.
The patient remained clinically stable for at least two months post-treatment.
A unique association between optic neuritis and HLA-B35 positivity was established in this case.

Implications:

The human leukocyte antigen (HLA)-B35 allele may be a risk factor for specific presentations of optic neuritis.
This case underscores the importance of considering HLA testing in atypical optic neuritis cases.
Further research into genetic factors influencing optic neuritis is warranted.