Primary Pulmonary Choriocarcinoma With Lymph Node Metastasis: A Case Report and Brief Review

Choriocarcinoma is a malignant germ cell tumor containing syncytiotrophoblasts and secreting human chorionic gonadotropin (β-hCG), often associated with a poor prognosis. Reports of primary choriocarcinoma of the lung with lymph node metastasis are extremely rare in the literature. Here, we report a surgically treated case of primary pulmonary choriocarcinoma in a 32-year-old woman. Surgery was followed by three cycles of chemotherapy with etoposide, methotrexate, actinomycin D, leucovorin calcium, cyclophosphamide, and vincristine. Her post-treatment PET scan showed no evidence of disease, and her β-hCG remains at nadir level. She is currently on monthly hCG surveillance and is in good condition.