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Updated: Jun 19, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Evaluation of the flying focal spot technology in a wide-angle digital breast tomosynthesis system
Katrien Houbrechts1, Nicholas Marshall1,2, Lesley Cockmartin2
1KU Leuven, Department of Imaging and Pathology-Medical Physics and Quality Assessment, Leuven, Belgium.
Purpose:
We characterize the flying focal spot (FFS) technology in digital breast tomosynthesis (DBT), designed to overcome source motion blurring.
Approach:
A wide-angle DBT system with continuous gantry and focus motion ("uncompensated focus") and a system with FFS were compared for image sharpness and lesion detectability. The modulation transfer function (MTF) was assessed as a function of height in the projections and reconstructed images, along with lesion detectability using the contrast detail phantom for mammography (CDMAM) and the L1 phantom.
Results:
For the uncompensated focus system, the spatial frequency for 25% MTF value ( ) measured at 2, 4, and 6 cm in DBT projections fell by 35%, 49%, and 59%, respectively in the tube-travel direction compared with the FFS system. There was no significant difference in for the front-back and tube-travel directions for the FFS unit. The in-plane MTF in the tube-travel direction also improved with the FFS technology.The threshold gold thickness ( ) for the 0.16-mm diameter discs of contrast detail phantom for mammography (CDMAM) improved for the FFS system in DBT mode, especially at greater heights above the table; at 45 and 65 mm improved by 16% and 24%, respectively, compared with the uncompensated focus system. In addition, improvements in calcification and mass detection in a structured background were observed for DBT and synthetic mammography. The FFS system demonstrated faster scan times (4.8 s versus 21.7 s), potentially reducing patient motion artifacts.
Conclusions:
The FFS technology offers isotropic resolution, improved small detail detectability, and faster scan times in DBT mode compared with the traditional continuous gantry and focus motion approach.
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