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Related Experiment Videos

Biocompatibility of haemoperfusion.

J H Rommes, B Sangster, L Berrens

    Archives of Toxicology
    |February 1, 1986
    PubMed
    Summary

    Haemoperfusion with activated charcoal columns significantly impacts hemodynamics and reduces complement, leucocyte, and thrombocyte levels. Close monitoring of hemodynamics is crucial during this procedure.

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    Why are we still mesmerized by the old fashioned Medicine Man?

    Minerva anestesiologica·2012

    Area of Science:

    • Cardiovascular Physiology
    • Immunology
    • Hematology

    Background:

    • Hemoperfusion is used to remove toxins but can cause adverse effects.
    • The impact of different hemoperfusion columns on physiological parameters requires further investigation.

    Purpose of the Study:

    • To evaluate the influence of hemoperfusion using cellulose-coated activated charcoal and polystyrene resin columns on hemodynamics, complement system, and blood cell concentrations.
    • To explore the relationship between observed hemodynamic changes, complement activation, and blood cell sequestration.

    Main Methods:

    • A controlled study involving three groups of five dogs each.
    • Hemoperfusion was performed using columns with cellulose-coated activated charcoal or polystyrene resin.
    • Hemodynamic parameters, complement activity, and leucocyte and thrombocyte concentrations were monitored.

    Main Results:

    • Hemoperfusion with activated charcoal columns caused significant decreases in mean aortic pressure, cardiac output, and stroke volume.
    • Both column types led to a decrease in leucocyte and thrombocyte concentrations due to sequestration.
    • Activated charcoal columns significantly reduced total hemolytic complement, indicating complement system activation.

    Conclusions:

    • Hemoperfusion, particularly with activated charcoal, induces significant hemodynamic changes and complement activation.
    • Transient decreases in blood cell counts are attributed to sequestration within the perfusion columns.
    • Close hemodynamic monitoring is essential during the early phase of hemoperfusion in intoxicated patients.

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