Emerging roles of N⁶-methyladenosine in arsenic-induced toxicity

Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety of events. As the most common form of methylation modification of RNA in eukaryotic cells, N⁶-methyladenosine (m⁶A) is widely involved in regulating RNA processing, translation and degradation, thus playing important role in various pathophysiological processes. Emerging studies have demonstrated that m⁶A modification is synergistically mediated by methyltransferases, demethylases and methyl-binding proteins. Recently, emerging studies have shown that m⁶A modification and its regulatory proteins play important roles in arsenic toxicity through mediating various key signaling pathways. We comprehensively analyzed the mechanisms by which m⁶A modification and its regulatory proteins contribute to arsenic toxicity. Our reviews offer a scientific foundation for the development of preventive and control strategies to mitigate arsenic-induced toxicity, with an emphasis on an epigenetic approach.