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Updated: Jun 5, 2025
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Atherogenic low-density lipoprotein and cardiovascular risk
Javier Hernando-Redondo1,2,3, Olga Castañer Niño2,4, Montse Fitó1,2
1Consorcio CIBER, Pathophysiology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, Madrid.
Current Opinion in Lipidology
|December 6, 2024
Summary
Advanced LDL particle analysis offers new insights into cardiovascular disease (CVD) risk beyond cholesterol levels. Oxidized LDL (oxLDL) is a key factor in atherosclerosis, with potential therapeutic targets identified.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Biomarker Discovery
Background:
- Residual cardiovascular risk persists despite LDL cholesterol reduction.
- LDL particle characteristics (count, size, modifications) influence atherosclerosis.
- Technological advancements enable detailed LDL particle profiling for biomarker development.
Purpose of the Study:
- To review the evolving role of LDL particles in atherosclerosis.
- To highlight recent advances in LDL biomarker measurement and application.
- To provide an updated overview of LDL's atherosclerotic mechanisms.
Main Methods:
- Comprehensive evaluation of lipoprotein subtypes.
- Analysis of oxidized LDL (oxLDL) atherogenic potential.
- Investigation of the oxidized LDL receptor 1 (LOX-1) in atherosclerosis.
Main Results:
- Small dense LDL is linked to increased CVD risk.
- Circulating oxLDL is a key factor in atherosclerosis onset and progression.
- Elevated oxLDL levels indicate higher CVD risk, though further research is needed.
Conclusions:
- LDL atherogenicity biomarkers can predict ischemic events.
- Diet and exercise may reduce LDL oxidation.
- Oxidized LDL is a therapeutic target; LDL-based nanocarriers show promise.
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