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Mortality of Acute Kidney Injury in Cirrhosis: A Systematic Review and Meta-Analysis of Over 5 Million Patients Across Different Clinical Settings

  • 0Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Alimentary Pharmacology & Therapeutics +

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December 6, 2024

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December 6, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Acute kidney injury (AKI) significantly increases mortality in cirrhosis patients. This risk is higher in intensive care units (ICU) and with acute-on-chronic liver failure (ACLF), influenced by AKI stage and onset.

Area Of Science

  • Nephrology
  • Hepatology
  • Critical Care Medicine

Background

  • Acute kidney injury (AKI) is a frequent complication in cirrhosis patients, often leading to poor outcomes.
  • Cirrhosis-associated AKI significantly worsens patient prognosis and survival rates.

Conclusions

  • Acute kidney injury substantially worsens the prognosis for patients with cirrhosis.
  • Prognosis is particularly dire for cirrhotic patients with AKI in the ICU or with ACLF.
  • AKI stage, timing of onset, and diagnostic criteria are critical factors influencing mortality in this patient population.

Keywords: