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Updated: Jun 5, 2025
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Coexisting Tubulointerstitial Inflammation and Damage Is a Risk Factor for Chronic Kidney Disease in Patients With
Hyemin Jeong1, Sung-Eun Choi1, Ji-Hyoun Kang1
1Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.
International Journal of Rheumatic Diseases
|December 6, 2024
Summary
Coexisting tubulointerstitial inflammation and damage in lupus nephritis patients significantly predicts chronic kidney disease progression. This finding highlights a key risk factor for long-term kidney function decline in lupus nephritis.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus.
- Predicting chronic kidney disease (CKD) progression in LN is crucial for patient management.
Purpose of the Study:
- To investigate if concurrent tubulointerstitial inflammation (TII) and tubulointerstitial damage (TID) predict CKD progression in LN patients.
Main Methods:
- Analysis of data from 175 LN patients at renal biopsy.
- Stratification into groups based on TII/TID presence.
- Use of Cox proportional hazard regression models to identify risk factors.
Main Results:
- 110 (62.9%) patients had coexisting TII/TID.
- Patients with TII/TID were older with higher ESR, proteinuria, and lower eGFR/hemoglobin.
- Coexisting TII/TID was associated with significantly higher CKD progression risk (aHR 2.667).
Conclusions:
- Coexisting TII/TID at LN onset indicates a heightened risk of kidney function deterioration.
- This predicts long-term CKD development in lupus nephritis patients.
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