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Growth hormone treatment in children in Israel: A large-scale retrospective database study

Yael Reichenberg1, Rachel Bello2,3, Bernice Oberman1

  • 1Dan-Petach Tikva District, Clalit Health Services, Tel Aviv, Israel.

Acta Paediatrica (Oslo, Norway : 1992)
|December 6, 2024
PubMed

Insights

Early growth monitoring is crucial for children with short stature, especially girls and minorities, to ensure timely recombinant growth hormone (GH) therapy and improve adult height outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Public Health

Background:

  • Short stature affects a significant pediatric population, necessitating evaluation of treatment pathways.
  • Recombinant growth hormone (GH) therapy is a key intervention for various short stature conditions.
  • Understanding treatment patterns in specific regions is vital for optimizing care.

Purpose of the Study:

  • To analyze the indications, patient demographics, and treatment timelines for recombinant GH therapy in Israeli children.
  • To identify factors influencing the initiation of GH therapy for short stature.

Main Methods:

  • Retrospective review of medical charts for 5148 children treated with GH from 2010-2021 in Israel.
  • Data collection included demographics, diagnosis, time to diagnosis, and GH therapy duration.
  • Analysis of population characteristics including socio-economic status and ethnicity.

Main Results:

  • Idiopathic short stature (ISS) was the most common indication (64.1%), followed by GH deficiency (GHD) (31.1%).
  • GH therapy was initiated at a mean age of 9.8 years, with males treated more frequently than females.
  • The cohort represented diverse socio-economic and ethnic groups, including high SES (51.2%), non-ultraorthodox Jews (78.2%), ultraorthodox Jews (13%), and Arabs (8.8%).

Conclusions:

  • Timely growth assessment in early childhood is essential for all children.
  • Particular attention should be given to females, low socio-economic status individuals, and minority groups for appropriate referral and treatment.
  • Optimizing GH therapy initiation can lead to improved final adult height outcomes.
Abstract

Keywords:
childrengrowth hormone deficiencygrowth hormone treatmentidiopathic short staturesmall‐for‐gestational age

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