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Surveys02:16

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Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
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Updated: Jun 5, 2025

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Factors Associated With Enrollment to a Decentralized Study.

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Electronic health record invitations significantly boosted enrollment in a large DNA sequencing study compared to email. Enhanced invitation design did not improve sign-ups, highlighting the need for targeted outreach to underrepresented groups.

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Area of Science:

  • Genomic Medicine
  • Clinical Trial Recruitment
  • Health Informatics

Background:

  • Decentralized research studies require effective patient recruitment strategies.
  • The mode and format of study invitations may influence enrollment rates.
  • Optimizing recruitment is crucial for the success of large-scale genetic research.

Purpose of the Study:

  • To evaluate the impact of invitation delivery method (electronic health record vs. email) on patient enrollment.
  • To determine if enhanced invitation formatting influences participation in a DNA sequencing study.
  • To identify demographic and clinical factors associated with enrollment rates in a decentralized research setting.

Main Methods:

  • Prospective comparison of invitation strategies for the Tapestry DNA Sequencing Research Study.
  • Phase 1: Randomized patients to electronic health record (EHR) portal or email invitations.
  • Phase 2: Randomized patients to standard or enhanced invitations delivered via EHR or email.

Main Results:

  • Higher enrollment rates were observed in Phase 2 (7.27%) compared to Phase 1 (2.52%).
  • Electronic health record invitations yielded significantly higher enrollment (OR, 1.56) than email invitations.
  • Enhanced invitation design did not significantly impact enrollment rates.
  • Women, older adults (50-70), White/non-Hispanic individuals, urban residents, and those with recent healthcare encounters showed higher enrollment.

Conclusions:

  • Electronic health record invitations are more effective than email for recruiting participants in large, decentralized studies.
  • Invitation design enhancements did not improve enrollment, suggesting focus should be on delivery channel.
  • Lower enrollment in men, younger individuals, non-White/Hispanic individuals, and rural residents necessitates targeted recruitment strategies.