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Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
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Prevalence and Incidence of Type 1 Brugada Pattern: A 30-Year Experience at Mayo Clinic

Pattara Rattanawong1, Carolyn Mead-Harvey2, Olubadewa A Fatunde1

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ.

Mayo Clinic Proceedings
|December 6, 2024
PubMed

Insights

The incidence of type 1 Brugada pattern has increased over 30 years, with higher prevalence than previously reported in the US. This Brugada pattern is more common in Black and Hispanic populations than suspected.

Area of Science:

  • Cardiology
  • Genetics
  • Epidemiology

Background:

  • Brugada pattern is an electrocardiogram (ECG) finding associated with an increased risk of sudden cardiac death.
  • Previous studies on the incidence and prevalence of Brugada pattern have varied.
  • Understanding temporal trends and demographic variations is crucial for risk stratification.

Purpose of the Study:

  • To determine the incidence and prevalence of type 1 Brugada pattern.
  • To analyze trends over three decades at Mayo Clinic.
  • To investigate racial and ethnic disparities in Brugada pattern incidence.

Main Methods:

  • Retrospective review of 5,381,186 ECGs from 2,304,809 patients (1992-2021).
  • Identification of type 1 Brugada pattern using systematic keyword search.
  • Calculation of incidence rates by decade and incidence rate ratios (IRRs) between racial groups.

Main Results:

  • Incidence of type 1 Brugada pattern increased significantly over three decades.
  • Overall prevalence (2010-2021) was 10.094 per 100,000 person-years.
  • Higher incidence observed in Hispanic White (3-fold) and Black (1.5-fold) patients compared to non-Hispanic White patients.

Conclusions:

  • The incidence of type 1 Brugada pattern has risen over the past 30 years.
  • The prevalence in the US is higher than previously estimated.
  • Type 1 Brugada pattern is more common in Black and Hispanic populations than previously recognized.
Abstract

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