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Updated: Jun 5, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Extemporaneous Compounding of Medicated Ointments
Karen Nagel1, Fatima Ali2, Sarah Al-Khudari2
1Midwestern University Chicago College of Pharmacy, Downers Grove, Illinois. knagel@midwestern.edu.
Abstract:
Topical preparations represent a large percentage of compounded prescriptions, particularly in the area of dermatology. Properties of ointment bases vary greatly, and active ingredients are frequently added as aqueous or alcoholic solutions. Currently, there are no quantitative guidelines stating the various water and alcohol absorption capacity of different bases. A short experiment was designed to quantitate the amount of water or alcohol that could be absorbed by a series of ointment bases of varying types. Our findings may be used to assist compounding pharmacists in deciding what base is most suitable to use when considering the amount of water, alcohol, or any similar solvent needed to compound the preparation. A general overview of issues related to topical medication compounding is also provided in this article.
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