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Updated: Jun 12, 2025

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED
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STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis
Maria Livia Sassano1, Robbe Van Gorp2, Geert Bultynck2
1Cell Death Research and Therapy Laboratory, Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Abstract:
The endoplasmic reticulum (ER) controls intracellular Ca2+ dynamics. Depletion of ER Ca2+ stores results in short-term activation of store-operated Ca2+ entry (SOCE) via STIM1/Orai1 at ER-plasma membrane (ER-PM) contact sites (MCSs) and the long-term activation of the unfolded protein response (UPR), securing ER proteostasis. Recent work by Carreras-Sureda and colleagues describes a bidirectional control between IRE1 and STIM1 within the ER lumen that regulates ER-PM contact assembly and SOCE to sustain T-cell activation and myoblast differentiation.
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