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A xanthene-based fluorescent probe capable of selectively detecting phosgene in living mouse model
Wanxia Gao1, Chen Wang1, Xin Yu2
1Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medi-cine, Jianghan University, Wuhan 430056, China.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|December 6, 2024
Abstract:
In this study, we introduced a novel fluorescent probe RNP, which demonstrated outstanding sensitivity and specificity for phosgene detection. Upon phosgene exposure, the probe exhibited rapid fluorescence turn-on within a short re-sponse time (6 s). RNP was also effective in both cellular and murine experiments, where fluorescence enhancement was observed in the respiratory tract of mice.
