Monitoring molecule translocation through plasmonic nanopores based on surface enhanced Raman scattering

To study the translocation behavior of molecules through nanopores, the gold plasmonic nanopores (GPNs) structures with high Raman activity are fabricated. The process of molecule translocation (via potential, concentration and pH) is studied by Surface Enhanced Raman Scattering (SERS). The electrostatic effect is found critical for the translocation direction and speed of model molecule. What's more, the characteristic blinking signal of rhodamine 6G (R6G) molecules translocating through the nanopores is observed with millisecond temporal resolution.