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Copper-albumin: what is its functional role?

S H Laurie, D E Pratt

    Biochemical and Biophysical Research Communications
    |March 28, 1986
    PubMed
    Summary

    Albumin-bound copper in animal blood primarily transports copper from the intestine to the liver. Its role elsewhere is uncertain, potentially serving as a storage form rather than general transport.

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    Area of Science:

    • Biochemistry
    • Metalloprotein Metabolism

    Background:

    • Copper's role in animal blood is often attributed to albumin binding.
    • Caeruloplasmin is suggested as the required transport form for copper enzyme incorporation.

    Purpose of the Study:

    • To re-evaluate the transport function of copper bound to albumin (Cu-albumin) in animal blood.
    • To investigate the specific roles of Cu-albumin beyond intestinal-to-liver transport.

    Main Methods:

    • Kinetic analysis of Cu-albumin reactions.
    • Review of existing literature on copper metabolism and protein binding.

    Main Results:

    • Cu-albumin's reaction kinetics do not support a general blood transport function.
    • Cu-albumin demonstrates a clear transport role only in the portal bloodstream, delivering copper from the intestine to the liver.
    • The function of Cu-albumin after liver uptake is uncertain, possibly storage or negligible.

    Conclusions:

    • Copper-albumin's primary established transport role is limited to the portal circulation.
    • Further research is needed to clarify the post-hepatic function of Cu-albumin.
    • Similar questions regarding the function of other metal-albumin complexes, like zinc and nickel, remain.

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