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Updated: Jun 5, 2025
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
A post-modified lanthanide metal-organic frameworks as ratiometric luminescent sensor for the visual detection of
Congmin Sun1, Xiao Liu2, Huimin Zhuo1
1School of Chemical Engineering and Technology, Hebei University of Technology, XiPing Dao 5340, Beichen District, Tianjin 300401, PR China.
Abstract:
5-Hydroxytryptamine (5-HT), a key neurotransmitter, is an important biomarker for carcinoid syndrome. We herein construct a ratiometric luminescent sensor by covalently coupling fluorescein 5-isothiocyanate (FITC) with lanthanide metal-organic frameworks (Ln-MOFs). In the presence of 5-HT, the emission of FITC increases while the emission of Eu3 + decreases, accompanied by a distinct color change of emission from orange to green. This sensor not only has the advantages of high sensitivity (LOD = 0.04 μM), fast response (30 s), excellent selectivity, and large ΔE*ab value (73), but can also be used for the detection of 5-HT in human serum and allow for instant visual detection with the assistant of smartphone. This ratiometric luminescent sensor offers an alternative avenue for early diagnosis of carcinoid syndrome.
