Related Experiment Video

Updated: Jun 5, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.8K

ILC1 as critical gatekeepers in autoimmune kidney damage

Cyril Seillet1,2, Le Xiong1,2

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Immunology and Cell Biology
|December 6, 2024
PubMed

Insights

Blocking NKp46 signaling reduces organ damage, identifying NKp46+ innate lymphoid cells type 1 (ILC1s) as therapeutic targets in autoimmune diseases like lupus nephritis.

Area of Science:

  • Immunology
  • Autoimmune Diseases
  • Renal Pathology

Background:

  • Natural Killer group 2D (NKG2D) receptor interactions are implicated in autoimmune disease pathogenesis.
  • NKp46 signaling blockade has demonstrated potential in reducing organ injury.

Purpose of the Study:

  • To investigate the role of NKp46+ innate lymphoid cells type 1 (ILC1s) in lupus nephritis pathogenesis.
  • To elucidate the mechanisms by which ILC1s contribute to kidney inflammation and tissue damage.

Main Methods:

  • Analysis of immune cell populations in lupus nephritis models.
  • Assessment of cytokine production by ILC1s.
  • Evaluation of macrophage infiltration and activation.

Main Results:

  • NKp46+ ILC1s were identified as key drivers of kidney inflammation in lupus nephritis.
  • These cells produce CSF2 (colony-stimulating factor 2), promoting pro-inflammatory macrophage expansion.
  • Macrophage infiltration into epithelial niches exacerbates tissue damage.

Conclusions:

  • NKp46+ ILC1s orchestrate kidney inflammation in lupus nephritis via CSF2 production.
  • Targeting NKp46+ ILC1s represents a potential therapeutic strategy for lupus nephritis and related autoimmune conditions.
Keywords:
inflammationinnate lymphoid cellssystemic lupus erythematosus (SLE)

More Related Videos

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection10:25

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.8K
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.8K

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
951