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ILC1 as critical gatekeepers in autoimmune kidney damage
Cyril Seillet1,2, Le Xiong1,2
1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Immunology and Cell Biology
|December 6, 2024
Abstract
None:
A recent article has shown that blocking NKp46 signaling reduces injury, highlighting these cells as key drivers of organ damage and potential therapeutic targets in autoimmune diseases. In lupus nephritis, NKp46+ ILC1s orchestrate kidney inflammation by producing CSF2, driving the expansion of pro-inflammatory macrophages that infiltrate epithelial niches and exacerbate tissue damage.
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