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Related Experiment Videos

Rapid decrease in high density lipoprotein subfractions and postheparin plasma lipase activities after cessation of

M Välimäki, E A Nikkilä, M R Taskinen

    Atherosclerosis
    |February 1, 1986
    PubMed
    Summary

    Regular alcohol consumption elevates high-density lipoprotein (HDL) levels, primarily HDL2. Abstaining from alcohol leads to a significant decrease in HDL2 concentration and altered lipase activities in chronic alcohol users.

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    Area of Science:

    • Cardiology
    • Biochemistry
    • Metabolic Disorders

    Background:

    • Regular alcohol intake is linked to increased high-density lipoprotein (HDL) levels.
    • The specific HDL subfraction affected by alcohol consumption remains debated.

    Purpose of the Study:

    • To investigate the impact of alcohol cessation on HDL subfractions (HDL2 and HDL3) in chronic alcohol users.
    • To analyze changes in lipid and protein concentrations within HDL subfractions.
    • To assess alterations in postheparin plasma lipase activities during alcohol abstinence.

    Main Methods:

    • Measurement of HDL subfraction lipid and protein concentrations.
    • Assessment of postheparin plasma lipoprotein lipase and hepatic lipase activities.
    • Sequential measurements during one week of total alcohol abstention in chronic alcohol users.

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    Main Results:

    • A significant 38% decrease in HDL2 mass concentration was observed within 8 days of alcohol abstinence.
    • HDL2 cholesterol, phospholipid, and protein levels decreased, while HDL2 triglyceride levels increased by 40%.
    • HDL3 mass concentration showed a non-significant 13% decrease, with similar proportional changes in its components and an increase in triglycerides.
    • Postheparin plasma lipoprotein lipase and hepatic lipase activities decreased by 41% and 37%, respectively.

    Conclusions:

    • Chronic alcohol consumption significantly increases HDL2 levels in alcoholics.
    • Alcohol cessation leads to a rapid decline in HDL2, suggesting it is the primary HDL subfraction influenced by alcohol.
    • Changes in lipase activities may contribute to the altered HDL subfraction metabolism observed during abstinence.