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Pre-pregnancy alcohol experience attenuates typical decrease in gestational alcohol consumption in mice.

H C Becker, C L Randall, R F Anton

    Alcohol (Fayetteville, N.Y.)
    |January 1, 1986
    PubMed
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    Mice reduced alcohol intake during pregnancy and lactation. However, prior alcohol exposure before pregnancy lessened this reduction, indicating alcohol experience influences consumption patterns.

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Reproductive Biology

    Background:

    • Alcohol consumption during pregnancy poses risks to fetal development.
    • Understanding factors influencing alcohol self-selection during gestation is crucial for public health.
    • Maternal alcohol use during pregnancy and lactation requires further investigation into behavioral patterns.

    Purpose of the Study:

    • To investigate the impact of pre-pregnancy alcohol consumption on voluntary alcohol intake during pregnancy and lactation in mice.
    • To determine if prior alcohol experience modifies the typical decrease in alcohol self-selection observed during gestation and nursing.

    Main Methods:

    • C57BL mice were provided a two-bottle choice between ethanol and water.
    • One group received the choice for three weeks pre-pregnancy, throughout gestation, and lactation.

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  • A second group initiated the choice on the first day of pregnancy.

    • Main Results:

    • Voluntary alcohol intake and preference significantly decreased during pregnancy and lactation compared to pre-pregnancy levels.
    • Mice with pre-pregnancy alcohol exposure showed a less pronounced reduction in alcohol consumption during pregnancy.
    • No correlation was found between the level of pre-pregnancy alcohol consumption and subsequent intake during pregnancy.

    Conclusions:

    • Maternal alcohol consumption is generally attenuated during pregnancy and lactation, irrespective of prior exposure.
    • Previous experience with alcohol influences the extent to which intake is reduced during pregnancy.
    • The precise mechanisms driving reduced voluntary alcohol consumption during pregnancy warrant further research.