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TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond

Qitong Wu1, Deeptashree Nandi1, Dipali Sharma2,3

  • 1Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

Cancer Metastasis Reviews
|December 7, 2024
PubMed

Insights

Tripartite motif 29 (TRIM29) significantly drives cancer progression, affecting growth, metastasis, and therapeutic response. Understanding TRIM29 regulation and dual roles is key for developing new cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Tripartite motif (TRIM) proteins, primarily E3 ubiquitin ligases, have diverse roles beyond ubiquitination.
  • TRIM29 is a key TRIM family member implicated in various physiological processes and diseases, particularly cancer.

Purpose of the Study:

  • To systematically review the regulation of TRIM29 in cancer.
  • To discuss TRIM29's influence on cancer progression, including growth, epithelial-to-mesenchymal transition, stemness, and metastasis.
  • To explore TRIM29's impact on metabolic interventions and cancer therapeutics, and its context-dependent oncogenic or tumor-suppressive functions.

Main Methods:

  • Literature review and synthesis of existing research on TRIM29.
  • Analysis of TRIM29's molecular mechanisms in potentiating oncogenic pathways.
  • Examination of regulatory mechanisms including non-coding RNAs, epigenetic, and post-translational modifications.

Main Results:

  • TRIM29 promotes cancer growth, epithelial-to-mesenchymal transition, stemness, and metastasis by activating oncogenic pathways.
  • TRIM29 influences metabolic interventions and affects cancer therapy efficacy.
  • TRIM29 expression is tightly regulated by non-coding RNAs, epigenetic, and post-translational mechanisms.

Conclusions:

  • TRIM29 plays a multifaceted role in cancer, acting as a significant driver of progression.
  • Understanding TRIM29's complex regulation and dual functions is crucial for improving cancer prognosis.
  • Targeting TRIM29 or understanding its interactions may lead to novel therapeutic strategies and personalized cancer care.
Keywords:
CancerOncogeneSignal transduction pathwaysTRIMTherapyTumor suppressor

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