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Thalamic changes in patients with chronic facial pain
Anton Pashkov1,2,3, Elena Filimonova4,5, Boris Zaitsev4
1FSBI "Federal Center of Neurosurgery", Nemirovich-Danchenko street, 132/1, 630087, Novosibirsk, Russia. antonpashkov03@gmail.com.
Neuroradiology
|December 7, 2024
Summary
Structural changes in the thalamus, particularly intralaminar and geniculate nuclei, are linked to chronic trigeminal neuralgia pain. Thalamic nuclei volume decreases with pain intensity and duration.
Area of Science:
- Neuroscience
- Radiology
- Pain Medicine
Background:
- Primary trigeminal neuralgia (TN) is a debilitating neuropathic pain condition.
- The thalamus plays a crucial role in pain processing and sensory integration.
- Understanding thalamic structural changes in TN is vital for pain management.
Purpose of the Study:
- To investigate structural alterations in individual thalamic nuclei in patients with primary TN.
- To examine thalamic remodeling in response to chronic pain.
- To correlate morphometric changes with clinical variables.
Main Methods:
- Magnetic resonance imaging (MRI) analysis of 62 TN patients and 28 healthy controls.
- Thalamic nuclei segmentation using FreeSurfer software.
- Statistical comparison of patient subgroups (right/left-sided pain) with controls and correlation analysis.
Main Results:
- Significant gray matter volume changes observed in thalamic nuclei of TN patients.
- Alterations noted in intralaminar and geniculate nuclei, not ventral nociceptive nuclei.
- No significant volume increase post-surgery; nuclei volumes negatively correlated with pain intensity and duration.
Conclusions:
- Preliminary findings reveal novel structural thalamic alterations in chronic TN.
- These findings suggest potential clinical applications for understanding and managing TN.
- Thalamic remodeling is associated with pain chronicity and intensity in TN.
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