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Bone resorption induced by middle-ear implants.

M D McGinn, R A Chole, S P Tinling

    Archives of Otolaryngology--Head & Neck Surgery
    |June 1, 1986
    PubMed
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    Expanding cholesteatomas may cause bone loss by exerting pressure. This study demonstrated that tympanic implants, mimicking cholesteatoma pressure, induced osteoclastic bone resorption in gerbils.

    Area of Science:

    • Otolaryngology
    • Bone Biology
    • Biomaterials Science

    Background:

    • Expanding cholesteatomas are suspected to cause bone resorption via pressure.
    • Previous studies showed expansive tympanic implants induce osteoclastic bone resorption.

    Purpose of the Study:

    • To investigate if pressure from tympanic implants can induce osteoclastic bone resorption.
    • To quantify the pressure exerted by various tympanic implant materials.

    Main Methods:

    • Gerbils received tympanic implants made of cartilage, silicone rubber, and Teflon.
    • Implant pressure was estimated using forces of gravity and surface tension.
    • Osteoclastic bone resorption was assessed in response to implant pressure.

    Main Results:

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    • Tympanic implants induced osteoclastic bone resorption.
    • Estimated pressures ranged from 2.1 X 10(-3) to 8.0 X 10(-3) dynes/sq cm (1.6 to 6.0 mm Hg).
    • These pressures are comparable to those exerted by cholesteatomas.

    Conclusions:

    • Pressure from tympanic implants, similar to cholesteatomas, can induce osteoclastic bone resorption.
    • This supports the hypothesis that cholesteatoma-induced pressure causes bone erosion.