TREM1-Microglia crosstalk: Neurocognitive disorders

Area of Science:

• Neuroscience
• Immunology
• Pathology

Background:

• Neurocognitive Disorders (NCDs) impair cognitive functions like memory and learning.
• Microglial inflammatory activation in the hippocampus is implicated in NCD pathogenesis.
• Pattern-recognition receptors on microglia play a role in CNS inflammation.

Purpose of the Study:

• To review the role of Triggering Receptor Expressed on Myeloid cells 1 (TREM1) in neurocognitive disorders.
• To elucidate TREM1's function in microglial activation and inflammation within the CNS.

Main Methods:

• Literature review of studies on TREM1, microglia, and neurocognitive disorders.
• Analysis of TREM1 expression and function in response to CNS injury and inflammation.

Main Results:

• TREM1 is upregulated on microglia during CNS injury and inflammation.
• TREM1 amplifies inflammatory responses, promoting microglial activation.
• Upregulated TREM1 contributes to the development of neurocognitive disorders.

Conclusions:

• TREM1 is a critical receptor in microglia-mediated inflammation.
• Targeting TREM1 may offer a therapeutic strategy for neurocognitive disorders.