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Lactylation modification in cardio-cerebral diseases: A state-of-the-art review

Zi Liao1, Bei Chen1, Tong Yang1

  • 1Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.

Ageing Research Reviews
|December 8, 2024
PubMed

Insights

Lactylation, a protein modification linked to lactate, impacts cardio-cerebral diseases (CCDs). Targeting lactylation offers a novel therapeutic strategy for treating these metabolic and inflammatory conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Cardio-cerebral diseases (CCDs) like heart disease and stroke are major health threats.
  • Metabolic abnormalities, particularly lactate accumulation, are central to CCD pathology.
  • Lactylation, a modification of proteins by lactate, influences cellular functions in CCDs.

Purpose of the Study:

  • To review the types and enzymes of lactylation.
  • To highlight lactylation's role in CCD pathological processes.
  • To explore lactylation as a therapeutic target for CCDs.

Main Methods:

  • Literature review of lactylation mechanisms and roles in CCDs.
  • Synthesis of clinical and preclinical evidence on lactylation.
  • Analysis of lactylation's impact on inflammation, angiogenesis, metabolism, and fibrosis.

Main Results:

  • Lactylation affects histone and non-histone proteins, modulating their function.
  • This modification is implicated in key pathological pathways of CCDs.
  • Enzymes regulating lactylation are potential therapeutic targets.

Conclusions:

  • Lactylation plays a significant role in the pathogenesis of cardio-cerebral diseases.
  • Targeting lactylation pathways presents a promising therapeutic avenue for CCDs.
  • Further research into lactylation could lead to innovative treatments for these conditions.

Keywords:
Cardio-cerebral diseasesLactateLactylationMetabolism

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