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  1. Home
  3. Dermatological Nanotechnology: Gelatin Films With O/w Emulsions For Skin Lesion Repair.
  1. Home
  3. Dermatological Nanotechnology: Gelatin Films With O/w Emulsions For Skin Lesion Repair.

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Dermatological Nanotechnology: Gelatin films with O/W emulsions for skin lesion repair.

Ayelen M Sosa1, Belen E Berín1, Celeste Cottet2

  • 1Universidad Nacional de Quilmes, Departamento de Ciencia y Tecnología, Laboratorio de Bio-Nanotecnología (LBN), Bernal, Buenos Aires, Argentina; Grupo de Biología Estructural y Biotecnología, Instituto Multidisciplinario de Biología Celular, Consejo Nacional de Investigaciones Científicas y Técnicas, CIC-PBA, UNLP, La Plata, Buenos Aires, Argentina.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|December 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Gelatin films with active ingredients show antimicrobial properties and promote skin healing. These biocompatible films are safe for human use and the environment, offering a promising treatment for skin injuries.

Keywords:
Antimicrobial activityBiopolymersNanocompositesToxicologyWound HealingZebrafish

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Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Wound healing technologies

Background:

  • Biopolymer-based innovations like films and hydrogels are increasingly used for skin injury treatment.
  • Assessing functionality, human safety, and environmental impact is crucial for these advanced materials.

Purpose of the Study:

  • To investigate the antimicrobial and wound-healing potential of gelatin films incorporating active ingredients.
  • To evaluate the biocompatibility and safety of these novel films in vitro and in vivo.

Main Methods:

  • Gelatin films with O/W emulsions encapsulating active ingredients (EA) were prepared.
  • Antimicrobial activity was tested against Pseudomonas aeruginosa and Staphylococcus aureus.
  • In vitro biocompatibility was assessed using human keratinocytes and murine fibroblasts.
  • In vivo toxicity was evaluated in zebrafish.
  • Keratinocyte migration assay was used to assess wound healing potential.

    • Main Results:

    • EA films demonstrated significant antimicrobial activity against tested bacteria.
    • Films showed excellent biocompatibility with cell cultures, maintaining cell viability and integrity.
    • No general or organ-specific toxicity was observed in the zebrafish model.
    • EA films enhanced keratinocyte migration, indicating wound healing promotion.

    Conclusions:

    • Gelatin films with encapsulated active ingredients show promise as safe and effective treatments for skin injuries.
    • The developed films possess antimicrobial properties, promote wound healing, and are biocompatible.
    • These findings support the potential application of these films in clinical settings and highlight their environmental safety.