Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

2
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
2
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

2
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
2
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

2
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
2
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

2
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
2
Mitral Regurgitation II: Clinical features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical features and Diagnostic Tests

2
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
2
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

4
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
4

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Roadmap to Revitalizing Academic Cardiovascular Medicine: A Perspective From the Association of Professors of Cardiology (APC) Emerging Leaders Group.

Journal of the American College of Cardiology·2026
Same author

Optimizing low-density lipoprotein cholesterol (LDL-C) management - a US physician survey of barriers and burdens.

American journal of preventive cardiology·2026
Same author

Undiagnosed and uncontrolled hypertension at a federally qualified health center.

Journal of human hypertension·2026
Same author

Gender Differences in Statin Discontinuation and Adherence Among Privately Insured People with HIV in the USA.

Journal of general internal medicine·2026
Same author

Post-Myocardial Infarction Guideline-Recommended Therapy Utilizing Sankey Diagrams Among Medicare Beneficiaries.

Journal of cardiopulmonary rehabilitation and prevention·2025
Same author

Blood pressure trajectories among people with and without HIV in a U.S.-based prospective cohort study.

AIDS (London, England)·2025

Related Experiment Video

Updated: Jun 5, 2025

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.0K

Left ventricular hypertrophy and ventricular ectopy in mitral valve prolapse.

Andrew P Cesmat1, Abdul M Chaudry2, Suhani Gupta3

  • 1University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.

International Journal of Cardiology
|December 8, 2024
PubMed
Summary

Left ventricular hypertrophy does not independently increase the risk of ventricular arrhythmia in mitral valve prolapse (MVP). Mitral valve structure and heart failure are key drivers of arrhythmia in MVP patients.

Keywords:
Arrhythmic mitral valve prolapseLeft ventricular hypertrophyMitral valve prolapseRisk stratificationVentricular arrhythmia

More Related Videos

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

15.9K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.4K

Related Experiment Videos

Last Updated: Jun 5, 2025

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.0K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

15.9K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.4K

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Valvular Heart Disease

Background:

  • Mitral valve prolapse (MVP) is associated with sudden cardiac death, potentially linked to increased ventricular mass.
  • The role of left ventricular hypertrophy (LVH) as a risk factor for ventricular arrhythmia in MVP remains unclear.

Purpose of the Study:

  • To investigate whether left ventricular hypertrophy (LVH) is an independent risk factor for complex or frequent ventricular ectopy (cfVE) in patients with mitral valve prolapse (MVP).

Main Methods:

  • A retrospective study of 629 MVP patients (aged 18-90) who underwent echocardiography.
  • Echocardiograms were analyzed for LVH, ventricular dimensions, function, and mitral valve pathology.
  • Ventricular arrhythmia was defined as complex or frequent ventricular ectopy (cfVE) via ECG or ambulatory monitoring. Logistic and Cox regression analyses were performed.

Main Results:

  • Left ventricular hypertrophy (LVH) was present in 22.4% of patients.
  • Patients with LVH showed a higher prevalence of cfVE (31.2%) compared to those without (17.8%).
  • Independent predictors of cfVE included mitral annular disjunction, bileaflet prolapse, heart failure, lower ejection fraction, coronary artery disease, and T-wave inversion. LVH was not an independent predictor (OR 1.22 [0.82-1.83], p=0.32).

Conclusions:

  • Left ventricular hypertrophy (LVH) is not an independent risk factor for ventricular arrhythmia in mitral valve prolapse (MVP).
  • Arrhythmia in MVP is primarily driven by mitral valve morphology and the presence of heart failure.
  • Further research is needed to elucidate the mechanisms underlying sudden death risk in MVP patients with increased ventricular mass.