Related Experiment Video
Updated: Jun 5, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Contribution of Visceral Systems to the Development of Substance Use Disorders: Translational Aspects of Interaction
Danil I Peregud1,2, Natalia V Gulyaeva2,3
1Serbsky National Medical Research Center for Psychiatry and Drug Addiction, Ministry of Health of the Russian Federation, Moscow, 119034, Russia. peregud_d@yahoo.com.
Abstract:
Substance use disorders are associated with structural and functional changes in the neuroendocrine, neuromediator, and neuromodulator systems in brain areas involved in the reward and stress response circuits. Chronic intoxication provokes emergence of somatic diseases and aggravates existing pathologies. Substance use disorders and somatic diseases often exacerbate the clinical courses of each other. Elucidation of biochemical pathways common for comorbidities may serve as a basis for the development of new effective pharmacotherapy agents, as well as drug repurposing. Here, we discussed molecular mechanisms underlying integration of visceral systems into the central mechanisms of drug dependence.
Related Concept Videos
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Drug Abuse and Addiction: Pharmacological Phenomena
Introduction to Biological Bases of Psychology
The nervous system, the cornerstone of...
Pathophysiology of Vomiting
Drug Dependence
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...

