Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

1.2K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.2K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

6.4K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamics of IDH1/2 mutated clones in acute myeloid leukemia challenge their use as universal MRD markers.

Blood cancer journal·2026
Same author

Association of hypomethylating agents + venetoclax in the real-life treatment of Myeloproliferative Neoplasms in blastic phase.

Leukemia research·2026
Same author

Pre-treatment circulating microRNA signatures predict outcomes of anti-CD19 CAR T-cell therapy.

Haematologica·2026
Same author

APL-like subset within <i>NPM1</i>-mutated AML: A distinct immunophenotype correlating with early vascular complications.

HemaSphere·2026
Same author

Compulsory admissions, mechanical restraints and staff attitudes toward coercion in a sample of psychiatric wards in Italy.

International journal of law and psychiatry·2026
Same author

Assessment of CMV infection in allo-HSCT recipients undergoing LMV prophylaxis by using an implemented diagnostic protocol to identify active viral replication.

Antiviral research·2026

Related Experiment Video

Updated: Jun 5, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.1K

Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms.

Eleonora Ceneri1, Alessia De Stefano1, Irene Casalin1

  • 1Department of Biomedical and Neuromotor Sciences, Cellular Signaling Laboratory, University of Bologna, Bologna, 40126, Italy.

Advances in Biological Regulation
|December 8, 2024
PubMed
Summary

Key signaling pathways in the bone marrow microenvironment (BMM) drive Myelodysplastic Neoplasms (MDS) progression by altering interactions between Mesenchymal Stromal Cells (MSCs) and Hematopoietic Stem Cells (HSCs). Targeting these pathways offers potential therapeutic strategies for MDS.

Keywords:
Bone marrow microenvironmentMyelodysplastic neoplasmsNF-κB signalingNotch signalingPhosphoinositide signalingTGF-β signaling

More Related Videos

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.7K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K

Related Experiment Videos

Last Updated: Jun 5, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.1K
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.7K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K

Area of Science:

  • Hematology
  • Cell Biology
  • Oncology

Background:

  • Myelodysplastic Neoplasms (MDS) are a group of clonal hematopoietic stem cell disorders.
  • The bone marrow microenvironment (BMM) plays a critical role in MDS pathogenesis.
  • Specific signaling pathways within the BMM are implicated in MDS progression.

Purpose of the Study:

  • To review the role of key signaling pathways in the BMM in MDS.
  • To elucidate how these pathways affect Mesenchymal Stromal Cells (MSCs) and Hematopoietic Stem Cells (HSCs).
  • To identify potential therapeutic targets for MDS.

Main Methods:

  • Literature review of signaling pathways in the BMM.
  • Analysis of the roles of Notch, PI-PLCs, TGF-β, and NF-κB in MDS.
  • Examination of MSC-HSC interactions within the MDS microenvironment.

Main Results:

  • Notch and PI-PLC signaling mediate intercellular communication.
  • TGF-β signaling promotes HSC quiescence and suppresses hematopoiesis.
  • NF-κB signaling contributes to an inflammatory microenvironment detrimental to hematopoiesis.

Conclusions:

  • Aberrant signaling pathways in the BMM are central to MDS development and progression.
  • These pathways disrupt normal hematopoiesis by altering MSC-HSC interactions.
  • Targeting these signaling pathways presents a promising therapeutic avenue for MDS.