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Published on: November 28, 2010
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Histologic Reaction Patterns of Lymph Node Involvement in Ovarian Serous Borderline Tumors
1From the Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea (J. Kim).
Archives of Pathology & Laboratory Medicine
|December 8, 2024
Summary
Histologic reaction patterns (HRPs) in lymph node involvement (LNI) of ovarian serous borderline tumors (SBTs) significantly impact recurrence-free survival. Certain HRPs indicate a worse prognosis, highlighting the importance of detailed LNI assessment in SBT patient outcomes.
Area of Science:
- Gynecologic pathology
- Tumor microenvironment
- Surgical pathology
Background:
- Lymph node involvement (LNI) in ovarian serous borderline tumors (SBTs) is common but its clinical significance remains unclear.
- Previous studies suggest LNI does not impact recurrence or survival in SBT patients, contradicting clinical observations.
Purpose of the Study:
- To investigate the association between histologic reaction patterns (HRPs) in LNI and SBT prognosis.
- To determine if specific HRPs correlate with patient outcomes, such as recurrence-free survival (RFS).
Main Methods:
- Comparison of HRPs around tumor cell clusters in LNs from SBT and low-grade serous carcinoma patients.
- Classification of HRPs into four categories (HRP 1-4) based on tumor cell location, adhesion, and desmoplastic reaction.
Main Results:
- LNI was associated with reduced RFS, but no recurrence was seen in patients with HRP 1 or 2 (free-floating tumor cells).
- HRP 3 or 4 (tumor cell adhesion or desmoplastic reaction) independently impacted RFS, but not overall survival.
Conclusions:
- The prognosis of SBT with LNI is not uniformly favorable and is significantly influenced by HRPs.
- Patients with HRP ≥3 demonstrate decreased RFS, indicating a poorer prognosis independent of overall survival.
