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Polarised light scanner for digital pathology.

Dunia Al Sheikhyaqoob1,2, André Oliveira3, Manuel Fella3

  • 1Institute for Pathology, Sana Klinikum Lichtenberg, Berlin, Germany. D_alsheikh@hotmail.com.

Virchows Archiv : an International Journal of Pathology
|December 8, 2024
PubMed
Summary

Digital pathology scanners can now perform polarized light analysis, crucial for diagnosing conditions like gout and amyloidosis. This study confirms the Glissando POL scanner provides comparable images to traditional polarized light microscopy.

Keywords:
Polarised light scannerArtificial intelligenceDigital pathologyGlissando POL scanner

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Area of Science:

  • Pathology
  • Medical Imaging
  • Optical Microscopy

Background:

  • Digital pathology offers remote work and AI integration but lacks polarized light analysis capabilities in conventional scanners.
  • Polarized light microscopy is essential for diagnosing various conditions, including crystal-induced arthropathies and amyloidosis.

Purpose of the Study:

  • To evaluate the comparability of digital images acquired using the Glissando POL scanner with those from conventional polarized light microscopy.
  • To determine if the Glissando POL scanner can be integrated into digital pathology workflows for polarized light analysis.

Main Methods:

  • Hematoxylin and eosin stained tissue sections from 75 cases were examined.
  • Images were acquired using both a conventional polarized light microscope and the Glissando POL scanner.
  • Comparative analysis of digital images from both methods was performed.

Main Results:

  • Images obtained using the Glissando POL scanner were comparable to those from conventional polarized light microscopy across all tested settings.
  • The scanner successfully captured polarized light features in various tissue types and pathological conditions.

Conclusions:

  • The Glissando POL scanner provides comparable results to traditional polarized light microscopy.
  • This technology can be safely integrated into digital pathology workflows, expanding its diagnostic capabilities.