Related Experiment Video
Updated: Jun 5, 2025
06:58
Culturing and Measuring Fetal and Newborn Murine Long Bones
Published on: April 26, 2019
8.2K
Trabecular Bone Ontogeny of the Human Distal Tibia
Rebecca A G Reid1, Catriona Davies1, Craig Cunningham1
1Centre for Anatomy and Human Identification, School of Science and Engineering, University of Dundee, Dundee, Scotland.
American Journal of Biological Anthropology
|December 9, 2024
Summary
The fetal distal tibia shows immature bone patterns, but by one year, it adapts to bipedal gait. After age one, the distal tibia develops structural heterogeneity for weight-bearing stresses.
Area of Science:
- Human Osteology
- Skeletal Development
- Biomechanics
Background:
- Trabecular bone adaptation to biomechanical forces is increasingly understood during development.
- The distal tibia's role in weight-bearing locomotion is significant, yet its ontogenetic trabecular patterns are understudied.
Purpose of the Study:
- To document ontogenetic trabecular patterns in the distal tibia.
- To analyze changes in the distal tibia's structural heterogeneity throughout development.
Main Methods:
- Analysis of 38 distal tibiae from 28 intrauterine weeks to 8 postnatal years.
- Utilized microcomputed tomography for quantitative volume of interest and qualitative whole bone mapping.
Main Results:
- Fetal and perinatal tibiae exhibit high bone volume fraction with immature organization.
- A decrease in bone volume fraction and early trabecular re-organization occur within the first year of life.
- Increased trabecular structural heterogeneity is observed in the distal tibia after one year of age.
Conclusions:
- Early distal tibia architecture reflects ossification, with bone mass accumulation for postnatal adaptation.
- Postnatal development, particularly the first year, shows decreased bone volume fraction linked to biomechanical shifts from bipedal gait and growth.
- After one year, the distal tibia adapts its trabecular structure to accommodate bipedal stresses, showing increased heterogeneity.
More Related Videos
06:59Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
2.2K
09:36Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
Published on: March 14, 2018
9.3K
Related Concept Videos
01:29Bone Formation by Intramembranous Ossification
5.5K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
5.5K
01:09Spongy Bone
4.1K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
4.1K
01:24Bone Formation by Endochondral Ossification
3.8K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
3.8K
01:09Changes in the Appendicular Skeleton with Age
1.8K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
1.8K
01:10Bones of the Lower Limb: Tibia and Fibula
2.8K
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
2.8K
01:27Compact Bone
11.1K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
11.1K