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Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
Celia Rufo-Martín1,2,3, Diego Infante-García4, José Díaz-Álvarez3
1Experimental Mechanics Laboratory, Mechanical Engineering Department, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA.
Advanced Materials (Deerfield Beach, Fla.)
|December 9, 2024
Summary
Researchers developed a novel printable bioresin for personalized medicine. This advanced material offers tunable properties and improved biostability, enabling new additive manufacturing applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Additive Manufacturing
Background:
- Personalized medicine requires advanced biocompatible materials beyond current additive manufacturing limits.
- Existing materials often lack the tunable mechanical, thermal, and biocompatibility properties needed for complex biomedical applications.
Purpose of the Study:
- To engineer a novel, printable bioresin with tailored properties for personalized medicine.
- To enhance biostability and mechanical performance through molecular modifications and material integration.
- To functionalize the bioresin with antibacterial and bone-growth-promoting agents.
Main Methods:
- Synthesized a bioresin composed of methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator.
- Incorporated high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical properties.
- Modified 3D printing processes to accommodate printable PMMA.
- Functionalized the bioresin with silver oxide (antibacterial) and hydroxyapatite (bone-growth promotion) at various ratios.
Main Results:
- Demonstrated agile printability of the novel bioresin.
- Achieved tunable mechanical, thermal, and biocompatibility properties through molecular modifications.
- Successfully integrated antibacterial and bone-growth-promoting agents.
- Showcased potential for multiscale structural tailoring to match native tissue properties.
Conclusions:
- The novel printable bioresin is a versatile platform for additive manufacturing in personalized medicine.
- The material exhibits adaptable properties suitable for real-life biomedical applications.
- This advancement extends beyond conventional additive manufacturing capabilities, offering new possibilities for tissue engineering and regenerative medicine.
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