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Cumulative maternal lifetime stress & child asthma: effect modification by BMI
Nicole B Ramsey1,2, Yueh-Hsiu Mathilda Chiu3, Hsiao-Hsien Leon Hsu3
1The Kravis Children's Hospital, Jack and Lucy Clark Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stress (Amsterdam, Netherlands)
|December 9, 2024
Summary
Maternal stress increases child asthma risk, especially in obese mothers. Pre-pregnancy body mass index significantly modifies this link, highlighting complex intergenerational effects on early childhood asthma.
Area of Science:
- Reproductive Health
- Pediatric Health
- Epidemiology
Background:
- Maternal psychosocial stress and child asthma associations show inconsistent findings.
- Potential modifying factors require further investigation.
Purpose of the Study:
- Examine maternal lifetime stress and child asthma link.
- Assess effect modification by maternal pre-pregnancy body mass index and race/ethnicity.
Main Methods:
- Life Stressor Checklist-Revised for maternal stress.
- Parent-report for child asthma.
- Multivariable logistic regression and varying coefficient modeling.
Main Results:
- Higher maternal stress associated with increased child asthma odds in obese mothers (OR 1.84).
- Stronger associations found with higher maternal pre-pregnancy body mass index.
- The strongest association was observed in the Black demographic group.
Conclusions:
- Maternal pre-pregnancy body mass index significantly modifies the maternal stress-child asthma association.
- Complex interactions are crucial for understanding intergenerational stress effects on early childhood asthma.
Keywords:
body mass indexchildhood asthmamaternal lifetime psychosocial stresspregnancy cohortprenatalrace/ethnicityMore Related Videos
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